Sophie Whitehead

Abstract Poly ADP-ribose polymerase (PARP) inhibitors are standard of care treatment for cancers with homologous-recombination deficiencies. Yet, as tumors develop resistance, complementary strategies are emerging, including targeting microhomology-mediated end joining (MMEJ). Given that PARP1 is widely described as a key promoter of MMEJ, one would expect PARP inhibition to suppress MMEJ, potentially making MMEJ inhibition redundant.

In this time where information is laid out for us at the click of a button, it is so easy to have a narrow and anxious mindset when it comes to accepting the big technological changes and advances in our lives. With the emergence of AI technologies like DALL E and the Chat GPT suite, there has almost been an uprise and fear, especially amongst creatives, with the looming existential questions of: what will be my job relevance? Is there a future for my practice?

The third day of this year's international climate negotiations — COP26 — focused on finance, headlined by the 4th High Level Ministerial Dialogue on long-term climate finance. Developed countries are inching closer to achieving the goal agreed in 2009 of mobilizing USD100 billion per year in climate finance to support developing countries, albeit after the 2020 deadline.