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Sopie Crux

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Articles

Deficiency of actin depolymerizing factors ADF/Cfl1 in microglia decreases motility and impairs memory

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By Marie Denise Roggan, Stefanie Poll, Felix C Nebeling, Sopie Crux
| BioRxiv
Abstract Microglia are highly motile cells that play a crucial role in the central nervous system in health and disease. Here we show that actin depolymerizing factors ADF and Cofilin1 (Cfl1) are key factors of microglia integrity and function. We found a profound morphological phenotype in absence of ADF and Cfl1 in microglia. In vivo two-photon imaging of microglia with ADF/Cfl1-KO revealed reduced microglial fine processes motility and impaired microglia migration towards a laser-induced lesion.
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