Sorab N. Dalal on Muck Rack

Sorab N. Dalal

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Articles

DKC1 promotes colorectal cancer progression and therapy resistance by dysregulating sphingolipid biosynthesis

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By Umar Khan, Ayush Goel, Shivansh Nigam, Nazia Chaudhary, Ayush Praveen, Anjan Roy, Fabeha Fatima, Akshay Shendre, Shannon Carskadon, Anjali Bajpai, Abhimanyu Kapoor, Abhijit Chandra, Avanish Saklani, Nallasivam Palanisamy, Dilpreet K. Sawhney, Afiya Dalwai, Anjali Tewari, Sorab N. Dalal
| Nature Verified
Abstract DKC1, a key coordinator of RNA modification and telomerase activity, has been implicated in colorectal cancer (CRC), yet its role in disease pathogenesis remains incompletely understood. We show that DKC1 drives CRC by promoting cell cycle progression, suppressing apoptosis, conferring stemness and drug resistance. Elevated DKC1 in CRC associates with poor prognosis and WNT-enriched Consensus Molecular Subtype 2 gene signature.
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