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Sothy Yi on Muck Rack

Sothy Yi

As seen in: The Journal of Immunology
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Articles

Characterization of a small molecule IRAK4 kinase inhibitor for the treatment of autoimmune and inflammatory diseases

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By Chrystelle Lamagna, Meagan Chan, Sothy Yi, Roy Frances, Stacey Siu
| The Journal of Immunology Verified
IRAK4 is a key protein kinase in immune cells. It is responsible for initiating MyD88-dependent signaling from most Toll-Like Receptors (TLR) and Interleukin-1 Receptors (IL-1R), resulting in downstream production of pro-inflammatory cytokines. Hence, inhibitors of IRAK4 kinase activity represent valuable therapeutic tools to treat cytokine-driven autoimmune and inflammatory diseases.
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In vitro and in vivo characterization of small molecule inhibitors of the anti-inflammatory TAM receptor MerTK

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By Alexander Owyang, Sothy Yi, Roy Frances, Sacha Holland, Sylvia Braselmann
| The Journal of Immunology Verified
MerTK, a TAM (Tyro3, Axl, MerTK) family RTK, is expressed on phagocytic cells. Its normal function is to dampen innate immune responses to self-antigens. MerTK is an indirect phosphatidylserine (PtdSer) receptor: PtdSer-binding TAM ligands (Gas6 or Protein S) bridge interactions between MerTK and PtdSer externalized on apoptotic cells (ACs), resulting in AC internalization (efferocytosis).
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