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Soudabeh Imanikia on Muck Rack

Soudabeh Imanikia

As seen in: Cell Press
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Articles by Soudabeh Imanikia

Tyramine Acts Downstream of Neuronal XBP-1s to Coordinate Inter-tissue UPRER Activation and Behavior in C. elegans

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By Neşem P. Özbey, Soudabeh Imanikia, Christel Krueger
| Cell Press Verified
Highlights • XBP-1s drives a distinct transcriptional program in C. elegans neurons • Neuronal XBP-1s requires tyramine synthesis to induce intestinal UPR activation • XBP-1s expression in RIM and RIC neurons drives cell non-autonomous UPR activation • Neuronal XBP-1s changes behavior and reproduction, dependent on tyramine synthesis Summary In C.
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XBP-1 Remodels Lipid Metabolism to Extend Longevity

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By Soudabeh Imanikia, Ming Sheng, Cecilia Castro Verified
| Cell Press Verified
Highlights • Xbp-1s expression decreases total fat but increases oleic acid (OA) levels • OA supplementation increases lifespan in wild-type, but not xbp-1-s-expressing, worms • Increased lysosomal lipase and Δ9 desaturase activity may underlie these changes • OA supplementation is sufficient to protect animals against proteotoxicity Summary The endoplasmic reticulum unfolded protein response (UPRER) is a cellular stress response that maintains homeostasis within the secretory pathway,...
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Neuronal XBP-1 Activates Intestinal Lysosomes to Improve Proteostasis in C. elegans

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By Soudabeh Imanikia, Neşem P. Özbey, Christel Krueger
| Cell Press Verified
Highlights • Xbp-1s expressed in the neurons or intestine of C. elegans improves proteostasis • Neuronal xbp-1s drives expression of lysosomal genes in the intestine • Intestinal lysosomes show enhanced acidity and activity upon xbp-1s expression • Lysosome function is required for xbp-1s to increase proteostasis and longevity Summary The unfolded protein response of the endoplasmic reticulum (UPRER) is a crucial mediator of secretory pathway homeostasis.
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