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Soundharya Ramu on Muck Rack

Soundharya Ramu

As seen in: Nature, BioRxiv
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Articles

TGF-β-producing tBregs are associated with poor survival rates in PTGS2-high cancers

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By Soundharya Ramu, Mohit Kumar Jolly, Bhavani Shankar, Kavitha Premkumar
| Nature Verified
Abstract The cues that cause B cells to adopt a regulatory phenotype are unknown. We previously reported on the regulatory B-T axis in mouse fibrosarcoma. This work demonstrates the presence of TGF-β-generating Bregs in the sarcoma microenvironment as well as variable gene expression depending on TGF-β levels. Breg depletion reduced tumor-evoked Bregs and progression of WEHI-164 fibrosarcoma, which was reversed by adoptive transfer of B cells.
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Multi-modal transcriptomic analysis unravels enrichment of hybrid epithelial/mesenchymal state and enhanced phenotypic heterogeneity in basal breast cancer

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By Sarthak Sahoo, Soundharya Ramu, Madhumathy G. Nair, Maalavika Pillai
| BioRxiv
Abstract Intra-tumoral phenotypic heterogeneity promotes tumor relapse and therapeutic resistance and remains an unsolved clinical challenge. It manifests along multiple phenotypic axes and decoding the interconnections among these different axes is crucial to understand its molecular origins and to develop novel therapeutic strategies to control it.
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