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Measurement of binding antibodies to SARS-CoV-2 variants elicited by natural infection and COVID-19 vaccines in a sub-Saharan African population

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By Eddy Kinganda Lusamaki, Ana M. Ortega-Villa, Daouda Camara, Julie Blie, Robin L. Dewar, Tauseef U. Rehman, Irini Sereti, Mary Smolskis, Renee Ridzon, Moussa Sidibe, Leonid Serebryannyy, Sandeep N. Narpala, Kathryn Shaw-Saliba, Dean Follmann, Sally Hunsberger, Mory Cherif Haidara, Nadie Coulibaly, Kade Kallon, Moses Mannah, Sow Fanta, Nella Bisento, Olivier Tshiani-Mbaya
| Nature Verified
Abstract Data on immune responses to COVID-19 vaccination in West and Central Africa remain limited, particularly across SARS-CoV-2 variants and vaccine platforms. Using the InVITE cohort in the Democratic Republic of Congo, Guinea, Liberia, and Mali, we evaluated anti-spike (anti-S) antibody binding to nine SARS-CoV-2 variants in 96 participants equally selected from pre-vaccination assay defined seropositive and seronegative groups.
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