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Soyu Zi

As seen in: Royal Society of Chemistry
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Articles

SIWV tetrapeptide and ROS-responsive prodrug conjugate for advanced glioblastoma therapy

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By Kyung Hee, Paramesh Jangili, Yoon Kyung Park, Soyu Zi
| Royal Society of Chemistry Verified
SIWV tetrapeptide and ROS-responsive prodrug conjugate for advanced glioblastoma therapy† Yoon Kyung Park,‡a Paramesh Jangili,‡b Soyu Zi, b Rae Hyung Kang,*c Dokyoung Kim *acdef and Jong Seung Kim *b Abstract A new conjugate formulation, SIWV-PB-SN, based on glioblastoma (GBM)-homing SIWV tetrapeptide and an ROS-responsive prodrug is reported. SIWV-PB-SN selectively penetrates the GBM cells and releases anti-GBM drug (SN-38) via ROS-induced linker cleavage.
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