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Spencer T Shah

As seen in: Nature, BioRxiv
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Articles

Activity-based selection for enhanced base editor mutational scanning - Nature Genetics

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By Spencer T Shah, Laura M Drepanos, Audrey Griffith
| Nature Verified
Abstract Base editing is a CRISPR-based technology that enables high-throughput, nucleotide-level functional interrogation of the genome that is essential for understanding the genetic basis of human disease and informing therapeutic development. Base editing screens have emerged as a powerful experimental approach, yet significant cell-to-cell variability in editing efficiency introduces noise that may obscure meaningful results.
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Activity-based selection for enhanced base editor mutational scanning

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By Ryan Steger, Eleanor G Kaplan, Spencer T Shah, Laura M Drepanos
| BioRxiv
Abstract Base editing is a CRISPR-based technology that enables high-throughput, nucleotide-level functional interrogation of the genome, which is essential for understanding the genetic basis of human disease and informing therapeutic development. Base editing screens have emerged as a powerful experimental approach, yet significant cell-to-cell variability in editing efficiency introduces noise that may obscure meaningful results.
Open in Who Shared Issue with article?
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