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Spoorthi Davala

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Articles

Inhibition of TET1 prevents the development of osteoarthritis and reveals the 5hmC landscape that orchestrates pathogenesis

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By Piera Smeriglio, Fiorella C. Grandi, Spoorthi Davala, Venkata Masarapu
| Science Magazine Verified
Preventing progression The etiology and progression of osteoarthritis, a disease of joint degeneration, remains incompletely known. Studying epigenetics in a mouse model of osteoarthritis, Smeriglio et al. found that ten-eleven-translocation enzyme 1 (TET1) regulated activation of WNT signaling, metalloproteinases, and mTOR via cytosine hydroxymethylation.
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