Sree Samanvitha Kuppa

ABSTRACT The excessive accumulation of monosodium urate crystals in joints leads to the pathological condition known as gout. While conventional treatments, which include Non-steroidal Anti-inflammatory Drugs, are available, their short half-life and low bioavailability limit their practical application.

Peptide derived from stromal cell-derived factor 1δ enhances the in vitro expression of osteogenic proteins via bone marrow stromal cell differentiation and promotes bone formation in in vivo models Mesenchymal stem cells (MSCs) rely on chemokines and chemokine receptors to execute their biological and physiological functions.

Abstract : Osteoarthritis (OA) is characterized by degeneration of the joint cartilage, inflammation, and a change in the chondrocyte phenotype. Inflammation also promotes cell hypertrophy in human articular chondrocytes (HC-a) by activating the NF-κB pathway. Chondrocyte hypertrophy and inflammation promote extracellular matrix degradation (ECM). Chondrocytes depend on Smad signaling to control and regulate cell hypertrophy as well as to maintain the ECM.