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Articles

C-Tb skin test to diagnose Mycobacterium tuberculosis infection in children and HIV-infected adults: A phase 3 trial

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By Henrik Aggerbeck, Statens Serum Institut, Morten Ruhwald, Søren T Hoff
| PLOS
In participants with microbiologically confirmed TB (n = 75; 45% HIV-infected) sensitivity of C-Tb, TST and QFT were similar (72% versus 75% versus 73%; p>0.5). All 3 tests had similar positivity rates in HIV-infected participants with active TB, however, positivity rates were reduced when CD4 counts were <100 cells/μL. In participants where active TB was excluded (n = 920), C-Tb (41%), TST (43%), and QFT (44%) also had similar test-positivity rates.
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By Morten Ruhwald, Jose Martinez, José Martinez, Henrik Aggerbeck, Rafael Vázquez Gallardo, Søren T Hoff, José I Villate, Bettine Borregaard, Ingrid Kromann, Antón Penas, Luis L Anibarro, Francisca Sánchez, Jose Ángel Rodrigo-Pendás
| secure.jbs.elsevierhealth.com
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