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Highlights • Anticipatory hepatic fed miRNAs are essential to attenuating fasting response • RISC association of miRNA-mRNA pairs oscillates during fed-fast cycles in the liver • Convergent additive action of miRNAs governs metabolic and mitochondrial homeostasis • Scavenging fed miRNAs impairs refed transition and affects whole-body energetics Summary Inability to mediate fed-fast transitions in the liver is known to cause metabolic dysfunctions and diseases.
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