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Srinivas Vinod Saladi on Muck Rack

Srinivas Vinod Saladi

As seen in: Nature, Science Magazine, Royal Society of Chemistry
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Articles

Autocrine CysLT 1 R-ERK/YAP signaling drives melanoma progression and reveals a targetable oncogenic GPCR axis

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By Lakshminarayan Reddy Teegala, Venkatesh Katari, Somayeh Darzi, Srinivas Vinod Saladi, Charles K. Thodeti, Sailaja Paruchuri, Ivana de la Serna
| Nature Verified
Abstract Cutaneous melanoma remains the most lethal skin cancer due to profound tumor heterogeneity and the frequent development of resistance to current therapies. Here, we identify the cysteinyl leukotriene receptor 1 (CysLT1R) as a previously unrecognized driver of melanoma progression. Analysis of bulk RNA-sequencing datasets from The Cancer Genome Atlas (TCGA) revealed significantly elevated CysLT1R transcript in metastatic tumors compared to primary tumors.
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KMT2D loss drives adeno-to-squamous transition and sensitizes TKI-resistant lung cancer to AURKA inhibition - Cell Death & Differentiation

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By Nana Chen, Zhaoyuan Fang, Zhengzhi Zou, Chong Chen, Srinivas Vinod Saladi, Hongbin Ji, Quentin Liu, Zifeng Wang
| Nature Verified
Abstract Lineage plasticity in non-small cell lung cancer (NSCLC) drives resistance to tyrosine kinase inhibitor (TKI) therapies, yet the epigenetic drivers of this phenotypic transition remain poorly defined. Here, we identify loss of the histone methyltransferase KMT2D as a critical event that disrupts adenocarcinoma lineage fidelity and promotes squamous transition.
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WSTF nuclear autophagy regulates chronic but not acute inflammation - Nature

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By Yaosi Liang, Kuo Du, Chia-kang Ho, Aaron Havas, Zhuo Zhou, Srinivas Vinod Saladi, Peter Adams, Anna Mae Diehl, Benjamin A. Alman, Zhenyu Yue, Xiao-fan Wang, Terje Johansen, Ulrike Rieprecht
| Nature Verified
Abstract Acute inflammation is an essential response that our bodies use to combat infections1. However, in the absence of infections, chronic inflammation can have a pivotal role in the onset and progression of chronic diseases, such as arthritis, cancer, autoimmune disorders, metabolic-dysfunction-associated steatohepatitis (MASH), and most ageing-associated pathologies2,3.
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