Srividya Makesh on Muck Rack

Srividya Makesh

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Short Polysialic Acid Counteracts Age-Related Synaptic and Cognitive Deficits

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By Shaobo Jia, Stepan Aleshin, Loris Frroku, Srividya Makesh
| biorxiv.org
Abstract Impaired activity of glutamate transporters, elevated concentration of extrasynaptic glutamate and hyperactivity of extrasynaptic GluN2B-containing NMDA receptors are common features in aging and several neurological conditions, including Alzheimer disease (AD). Previous studies revealed that polysialic acid (polySia), a glycan predominantly carried by the neural cell adhesion molecule NCAM, inhibits extrasynaptic NMDA receptors and supports synaptic plasticity in healthy adult brains.
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