By Stan Deresinski, MD, FIDSA Synopsis: The Centers for Disease Control and Prevention investigated the cases of two patients: a child with meningoencephalitis due to Naegleria fowleri and a man with Acanthamoeba granulomatous encephalitis. Both were associated with exposure to water and both were fatal. Sources: Dulski TM, Montgomery F, Ramos JM, et al. Fatal case of splash pad-associated Naegleria fowleri meningoencephalitis — Pulaski County, Arkansas, September 2023. MMWR Morb Mortal Wkly Rep.