Steen Knudsen

1 Introduction The distribution and genetic diversity of the Earth's flora and fauna were influenced greatly by Late Quaternary environmental fluctuations (Hewitt 2000). Many terrestrial species follow a general pattern, in which cold-adapted species expand their range towards lower latitudes during glacial periods and retract to high-latitude (or alpine) refugia during interglacial periods (Stewart et al. 2010).

PLOS ONE, Aug 2023 Purpose Dovitinib is a receptor tyrosine kinase inhibitor of VEGFR1-3, PDGFR, FGFR1/3, c-KIT, FLT3 and topoisomerase 1 and 2. The drug response predictor (DRP) biomarker algorithm or DRP-Dovitinib is being developed as a companion diagnostic to dovitinib and was applied retrospectively.