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Across the stages: a multiscale extension of the generalized stochastic microdosimetric model (MS-GSM2) to include the ultra-high dose rate
1 Introduction Ultra-high dose rate (UHDR) irradiation, sometimes also referred to in the literature as FLASH irradiation, is a novel technique based on fast beam delivery, with a total irradiation time < 100 ms and an overall dose rate > 40 Gy/s for a single high enough dose, usually exceeding 10 Gy. It has been extensively demonstrated experimentally [1–5] that FLASH irradiation allows obtaining a higher sparing of normal tissue, e.g., a decrease in memory loss [6, 7] or less intestine...
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