Stefan Constantinescu
Brussels
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Articles by Stefan Constantinescu
Selective dependency of CALR-mutant myeloproliferative neoplasms on TYK2 signaling
Abstract Myeloproliferative neoplasms (MPN) are driven by the oncoproteins JAK2V617F, mutant calreticulin (CALR), and mutant thrombopoietin receptor (TPOR; MPL), all of which activate JAK/STAT signaling. While JAK2 signaling is engaged in all MPNs, TYK2 is dispensable for JAK2V617F-driven disease. Here, we hypothesized a distinct role for TYK2 in CALR-mutant driven MPN. We found constitutive TYK2 phosphorylation in CALRdel52/ins5- and MPLW515K- but not JAK2V617F-expressing cells.
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Molecular pathogenesis of myeloproliferative neoplasms: Where do we stand in 2023?
Corresponding Author Stefan N. Constantinescu Université catholique de Louvain and de Duve Institute, Brussels, Belgium Department of Hematology, Cliniques universitaires Saint-Luc, Brussels, Belgium Ludwig Institute for Cancer Research Brussels, Brussels, Belgium WelBio Department, Wel Research Institute, Wavre, Belgium Ludwig Institute for Cancer Research, Nuffield Department of Medicine, Oxford University, Oxford, UK Correspondence Stefan N.
SRSF2-P95H decreases JAK/STAT signaling in hematopoietic cells and delays myelofibrosis development in mice - Leukemia
Abstract Heterozygous mutation targeting proline 95 in Serine/Arginine-rich Splicing Factor 2 (SRSF2) is associated with V617F mutation in Janus Activated Kinase 2 (JAK2) in some myeloproliferative neoplasms (MPNs), most commonly primary myelofibrosis. To explore the interaction of Srsf2P95H with Jak2V617F, we generated Cre-inducible knock-in mice expressing these mutants under control of the stem cell leukemia (Scl) gene promoter.
Calreticulin del52 and ins5 knock-in mice recapitulate different myeloproliferative phenotypes observed in patients with MPN
Abstract Somatic mutations in the calreticulin (CALR) gene are associated with approximately 30% of essential thrombocythemia (ET) and primary myelofibrosis (PMF). CALR mutations, including the two most frequent 52 bp deletion (del52) and 5 bp insertion (ins5), induce a frameshift to the same alternative reading frame generating new C-terminal tails. In patients, del52 and ins5 induce two phenotypically distinct myeloproliferative neoplasms (MPNs).
Advances in covalent kinase inhibitors
Advances in covalent kinase inhibitors Ayah Abdeldayem,†ab Yasir S. Raouf,†ab Stefan N. Constantinescu,c Richard Moriggl d and Patrick T.
India's government and BlackBerry reach an agreement, ready to teleport to 1984
After nearly being banned in India in 2010, BlackBerry has finally reached an agreement with the Indian government regarding surveillance in the name of security. According to a leaked document from the country's Department of Telecommunications that was obtained by The Times of India, it'll soon be possible for the government to see who you're emailing, who you're BBMing, the read-states of your BBM messages and even which websites you're visiting (hello!).
Knock-in of murine Calr del52 induces essential thrombocythemia with slow-rising dominance in mice and reveals key role of Calr exon 9 in cardiac development
Abstract Frameshifting mutations (−1/+2) of the calreticulin (CALR) gene are responsible for the development of essential thrombocythemia (ET) and primary myelofibrosis (PMF). The mutant CALR proteins activate the thrombopoietin receptor (TpoR) inducing cytokine-independent megakaryocyte progenitor proliferation. Here, we generated via CRISPR/Cas9 technology two knock-in mouse models that are heterozygous for a type-I murine Calr mutation.
Here is Samsung's 2013 tablet portfolio
Now that Samsung has officially announced the Galaxy Tab 3, it’s time to start thinking about the rest of their tablet portfolio. According to a leak on SamMobile, the company has three new major products in the pipeline. The first one is called the “Galaxy Tab 8.0”. As the name suggests, it’ll have an 8 inch screen, but what makes it special is that it’ll use AMOLED technology and it’ll do FullHD (1920 x 1080 pixels).
No one wants the HTC First, so it's going to be discontinued
It looks like no one wants the “Facebook Phone”, at least according to BGR, who says that sales of the HTC First at AT&T have been so bad that the company has decided to discontinue the device. How bad is bad? They say less than 15,000 units have been sold since the device launched in mid-April. That’s pretty horrible considering how big AT&T is. Now granted, this is still a rumor, but let’s pretend for a second it’s true. Why did the First fail?
Episode 142 | The Voicemail
Stefan and James went long this week, partly because Stefan couldn’t stop gushing about his new iPhone, and partly because James can’t get anyone to fix his phone. The two also discussed: Note: You can subscribe via RSS or iTunes.
Apple has announced an event for March 9-here’s what to expect
Apple will host another of its famous product events on March 9 in San Francisco. What’s in store? Apple Watch It’s widely expected that this is where the company will unveil more details about the Apple Watch, which is set to ship sometime in April. Apple’s invitation to media.(Screenshot)This will likely include any remaining features, a handful of launch applications from Apple and third-party developers, a concrete ship date, and pricing details.
Exactly why Xiaomi’s new Mi Note is “the best phone you can’t get in America”
Xiaomi, China’s fast-rising electronics company, recently released a new flagship phone called the Mi Note. The company is not going to sell it in the US, but several US-based publications have just tested it. Here’s what they thought—emphasis ours. “It looks and feels like a device from a company that’s been doing this for a long time,” but at the same time “it’s generic and sterile,” says The Verge’s Chris Ziegler.
Apple’s grand ambitions for the Apple Watch are suddenly clearer
The new Pebble Time smartwatch launched on Kickstarter today and has already received 30,000 pre-orders, totaling more than $6 million. What stands out about the $200 watch—besides its color screen and famously long battery life—is its new, simple “Timeline” interface, which seems impressively easy to use. How it works: On the right-hand side of the Pebble Time, there are three buttons. Each moves the watch timeline—the way it organizes events—in a different direction.
Here’s another smartwatch the Apple Watch is probably going to steam past
Pebble, whose original smartwatch was one of the first Kickstarter mega-hits, is back at it. The firm is expected to unveil a new model of its wrist-worn notification device tomorrow. Before revealing any details, however, someone has uploaded this image of a watch to Pebble’s website, which was noticed by 9to5Google. According to 9to5Google, the new Pebble will have a color screen, and will be thinner than its previous model, yet still maintain its robust, week-long battery life.
In the near future, your face will be your ID
Click, the BBC’s technology news program, recently profiled a US company called FaceFirst, which specializes in facial recognition technology. The California-based firm builds software that uses more 16,000 data points—like the distance between eyes—to identify an individual. It also provides a service to law enforcement officials and airports so captured faces can be compared against a list of people who may be on watch lists or even wanted lists.
Qualcomm’s latest smartphone chips keep it ahead of the pack
Building a smartphone once required armies of engineers who knew how to design wireless radios and processors and software developers who could write the grossly complicated code to make all those parts sing together. Then Qualcomm came along and introduced the world to “Snapdragon”—a so-called “system on a chip”—that includes everything needed to make a mobile phone except for the screen and software. Google solved the software problem with Android. And displays are easy to come by.
Twelve are dead after gunmen attacked Charlie Hebdo, the French magazine that published Muhammad cartoons
Three gunmen stormed the offices of a French satirical magazine called Charlie Hebdo around lunchtime on Wednesday (Jan. 7), brandishing AK-47s and a rocket launcher. The assailants killed 12 people and wounded five others. Among those dead are the magazine’s publisher, Stéphane Charbonnier; three cartoonists: Jean Cabut, Georges Wolinski, and Bernard Verlhac; and writer and economist Bernard Maris. Gérard Biard, the magazine’s editor-in-chief, was in London at the time.
Map: Here’s where Uber is and isn’t outlawed
You’ve probably read a story or two about Uber this month. The car-sharing service has been banned in India and Thailand following alleged rapes in each of those countries, and in Spain because it competes with local taxi companies. The company also has been sued by the city of Portland, Oregon, because it’s failing to comply with local regulations.
Almost no-one is using the new version of Android
Apple recently had to reveal a rare piece of disappointing news: That adoption of its latest mobile operating system, iOS 8, has been happening more slowly than the previous version last year. But even that is lightning-speed, compared with the adoption rate for Google’s new Android OS release. According to the latest Android developer stats, Lollipop—the nickname for Android version 5.0—is installed on so few devices that it fails to even register on the charts.
The future is finally here: We have jetpacks
To gaze upon the sky and watch majestic birds cut through the wind is both a humbling and a frustrating experience. Humbling because it makes our species realize that we were put on this earth to stand on two heavy pillars locked forever to the dirt, and frustrating because we want what we can’t have and will do everything in our power to obtain it. Enter the jetpack. For decades, the jetpack has been one of the iconic symbols of the future that was always just around the corner.
The best live-blogs, live streams and Twitter feeds for following Hong Kong’s “Umbrella Revolution”
The situation in Hong Kong is escalating. Protestors have swarmed around two important government buildings. The first is chief executive CY Leung’s residence. The second is the Central Government Complex. Police have issued warnings and are standing by to keep the buildings secure. To help you follow the action as it unfolds, here’s a list of some of our favorite sources: Live-blog: The Wall Street Journal’s China Realtime blog is posting articles and photos from the ground.
Say hello to the hideous new USB 3.0 cable your new smartphone or tablet will come with
Posted by Stefan Constantinescu on Sep 05, 2013 in Components Samsung’s Galaxy Note III is going to be the first phone on the market to feature a micro USB 3.0 connector. As The Verge notes, there are many obvious benefits to the new USB standard, the most important of which being the ability to draw 900 milliamps of current when connected to a computer versus 500 milliamps today. That’s all well and good until you see the cable.
Stock Android edition Samsung GS4 and HTC One hit Google Play Store
Look, you said you wanted pure Android. You said custom skins were always second best. Well, today's the day to show Samsung and HTC that you're not just all talk. The two best Google-powered phones on the market, Samsung's Galaxy S 4 and HTC's One, are now available directly from the Play Store running an unadulterated version of the OS. The One will set you back $599 and it comes with 32GB of non-expandable storage.
We knew we sucked at software back in 2000
Former Nokia CEO: 10 years ago we knew we had to work on our software, but we didn’t May 6, 2012 by Stefan Constantinescu - 7 Comments Jorma Ollila (pictured above, orange tie) isn’t a name that’s familiar to most folks, but it should be. He was Nokia’s CEO between 1992 and 2006, otherwise known as the years when a small Finnish company known for making cables transformed itself into the world’s largest mobile phone maker.
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