Stefan Johan Nezic on Muck Rack

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Articles

Proteasome inhibition enhances latency reversal and boosts NK cell-mediated elimination of HIV-1 infected cells through HLA-E downregulation

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By Thessa Laeremans, Sabine den Roover, Stefan Johan Nezic, Sabine Danielle Allard
| biorxiv.org
Abstract The shock and kill strategy primarily depends on using latency reversal agents (LRAs) to reactivate the dormant viral reservoir, rendering it visible for recognition and subsequent elimination by the host’s immune system. While this approach has shown high efficacy in vitro and ex vivo, its in vivo application has yet to show significant delays in time to viral rebound.
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