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Stefania Del Prete on Muck Rack

Stefania Del Prete

As seen in: Nature, BioRxiv
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Articles

Activated ATF6α is a hepatic tumour driver restricting immunosurveillance - Nature

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By Clementine Druelle-Cedano, Charlotte Rennert, Júlia Huguet-Pradell, Laimdota Zizmare, Pierluigi Ramadori, Vikas Ranvir, Peng Shen, Mihael Vucur, Olivia Coleman, Miray Cetin, Stefania Del Prete, Mohammad Rahbari, Aihua Sun, Li Gu, Laura Kim, Suchira Gallage, Nana Talvard-Balland, Albert Gris-Oliver, Alessio Bevilacqua, Pooja Sant, Jun-Hoe Lee, M. Simon, Sven Nahnsen, Almut Schulze, Ping-Chih Ho, Jan-Philipp Mallm, Darjus F. Tschaharganeh, Stephanie Roessler, Bertram R Bengsch, Geoffroy Andrieux, Melanie Boerries, Nisar P. Malek, Marco Prinz, Achim Weber, Robert Zeiser, Peter Bronsert, Konrad Kurowski, Robert Thimme, Detian Yuan, Tom Luedde, Roser Pinyol, Felix J. Hartmann, Michael Karin, Alpaslan Tasdogan, Christoph Trautwein, Moritz Mall, Maike Hofmann, Dirk Haller, Randal J. Kaufman, Cynthia Lebeaupin, Aikaterini Kadianaki, Niklas Vesper, Robert Stefan Piecyk, Menjie Qiu, Mirian Fernández-Vaquero, Insook Jang
| Nature Verified
Abstract Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer-related mortality and there are limited therapies1. Although endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) are implicated in HCC, the involvement of the UPR transducer ATF6α remains unclear2.
Open in Who Shared Issue with article?

Four Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage - Nature Communications

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By Stefania Del Prete, Anja Schneider, Oliver Stegle, Edith Heard
| Nature Verified
Abstract The Four Core Genotypes (FCG) is a mouse model system used to disentangle the function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the X chromosome has translocated to the YSry- chromosome and thus increased the expression of X-linked genes including the single-stranded RNA sensor and autoimmune disease mediator Tlr7. This previously-unreported X-Y translocation complicates the interpretation of studies reliant on C57BL/6J FCG mice.
Open in Who Shared Issue with article?

Four-Core Genotypes mice harbour a 3.2MB X-Y translocation that perturbs Tlr7 dosage

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By Jasper Panten, James Cleland, Lauren Saunders, Stefania Del Prete
| BioRxiv
Abstract The Four Core Genotypes (FCG) is a mouse model system heavily used to disentangle the function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the X chromosome has translocated to the YSry- chromosome and thus increased the expression of multiple genes including the auto-immune master regulator Tlr7. This previously-unreported X-Y translocation complicates the interpretation of studies reliant on FCG mice.
Open in Who Shared Issue with article?
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