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Stefania Mantovani

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Articles

Inhibition of the SerpinB3/protease-activated receptor 2 axis reduces liver cancer development and affects lipid metabolism

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By Pietro Guerra, Gianmarco Villano, Claudia M. Rejano-Gordillo, Clàudia Gil-Pitarch, Mariagrazia Ruvoletto, Alessandra Biasiolo, Santina Quarta, Irene González-Recio, Naroa Goikoetxea-Usandizaga, Arantza Sanz-Parra, Alessandro Gambella, Silvia De Siervi, Barbara Oliviero, Stefania Mantovani, Silvia Cagnin, Andrea Martini, Cristian Turato, Stefania Cannito, Maria Guido Verified, Maurizio Parola, Maria Luz Martinez-Chantar, Patrizia Pontisso, L. Estefanía Zapata-Pavas, Patricia Peña- SanFelix, Jon Ander Barrenechea-Barrenechea, Jessica Nurcis
| Nature Verified
Abstract MASLD and HCC are increasing challenges in hepatology. 1-Piperidinepropionic acid (1-PPA), a protease-activated receptor 2 (PAR2) inhibitor, downregulates SerpinB3, a molecule involved in fibrosis and HCC. This study investigates the effects of 1-PPA on lipid accumulation and HCC development. 1-PPA was employed in primary hepatocytes and human liver organoids cultured with steatogenic compounds and lomitapide, a VLDL-formation inhibitor.
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Hepatitis C Virus and the Host: A Mutual Endurance Leaving Indelible Scars in the Host’s Immunity

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By Mario U Mondelli, Barbara Oliviero, Stefania Mantovani, Sabrina Ottolini
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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TLRs: Innate Immune Sentries against SARS-CoV-2 Infection

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By Stefania Mantovani, Stefania Varchetta, Alessandra Renieri, Barbara Oliviero
| MDPI
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
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