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Stefanie M Puglielli on Muck Rack

Stefanie M Puglielli

As seen in: Future Medicine
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Articles

Gastrointestinal adverse events with combination of checkpoint inhibitors in advanced melanoma: a systematic review

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By Jill Bell, Aaron Galaznik, Stefanie M Puglielli, Elizabeth S Mearns
| Future Medicine Verified
Introduction: Immunotherapies, including checkpoint inhibitors (CIs) such as cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed death-1 (PD-1) inhibitors, are revolutionizing the treatment of advanced melanoma. Combining CTLA-4 and PD-1 inhibitors provides additional clinical benefit compared with single agents alone. However, combination therapy can increase the incidence of gastrointestinal adverse events (GI AEs).
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