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CD93—An emerging vascular target in cancer therapy
ADEAE antibody-dependent experimental autoimmune encephalomyelitis AJ adherens junction AML acute myeloid leukaemia CAR chimeric antigen receptor CGGA Chinese Glioma Genome Atlas CLEC14A C-type lectin domain containing 14A CML chronic myeloid leukaemia CTLD C-type lectin domain EAE experimental autoimmune encephalomyelitis ECM extracellular matrix EGF epidermal growth factor EGF R epidermal growth factor receptor ERK extracellular signal-regulated kinase ERM ezrin-radixin-moesin FAK focal...
Trogocytosis of chimeric antigen receptors between T cells is regulated by their transmembrane domains
Editor’s summary T cells can exchange certain membrane-bound proteins in a carefully controlled process called trogocytosis. The mechanisms that fine-tune T cell trogocytosis remain to be determined. Using human and murine chimeric antigen receptor (CAR) T cells, Barbera et al. identified that T cells actively transfer CARs via trogocytosis, which allows recipient T cells to acquire antitumor immunity.
257 Armed CAR-T cells for treatment of lymphoma and glioblastoma
http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial.
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