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Synthesis of β‐N‐Heterocyclic‐Cyclobutane‐Fused Bicyclic γ‐Lactones from 2‐Hydroxycyclobutanone and Carboxamide‐Bearing Wittig Reagents
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Synthesis of β‐N‐Heterocyclic‐Cyclobutane‐Fused Bicyclic γ‐Lactones from 2‐Hydroxycyclobutanone and Carboxamide‐Bearing Wittig Reagents
1 Introduction Molecular scaffolds incorporating cyclobutane rings[1] are key frameworks of many natural products and bioactive compounds, where they are frequently fused to heterocyclic moieties;[2] some representative examples are depicted in Figure 1.
Acid‐Promoted Structural Reorganization of Pull-Pull Alkylidenecyclobutanes: A Cascade Synthesis of Three‐Substituted γ‐Butyrolactones
1 Introduction In recent years, the preparation of complex organic products based on reorganization of the molecular frameworks of readily available compounds has attracted broad attention within the synthetic community.[1, 2] Ring strain-enabled reactions[3] are one of the most commonly used approaches to achieve structural reorganization efficiently, providing access to new chemical space for biologically active compounds and the generation of complexity in total synthesis.[4] As a result...
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