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Stefano Casarin

As seen in: Nature, The BMJ, BioRxiv
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Articles

Agent-based modeling of cellular dynamics in adoptive cell therapy

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By Yujia Wang, Stefano Casarin, May Daher, Vakul Mohanty, Merve Dede, Mayra Shanley, Eleonora Dondossola, Ludovica La Posta, Rafet Basar, Katayoun Rezvani, Ken Chen
| Nature Verified
Abstract Adoptive cell therapies (ACT) leverage tumor-immune interactions to cure cancer. Despite promising phase I/II clinical trials of chimeric-antigen-receptor natural killer (CAR-NK) cell therapies, molecular mechanisms and cellular properties required to achieve clinical benefits in broad cancer spectra remain underexplored. While in vitro and in vivo experiments are essential, they are expensive, laborious, and limited to targeted investigations.
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Agent-based modeling of cellular dynamics in adoptive cell therapy

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By Yujia Wang, Stefano Casarin, May Daher, Vakul Mohanty
| BioRxiv
Abstract Adoptive cell therapies (ACT) leverage tumor-immune interactions to cure cancer. Despite promising phase I/II clinical trials of chimeric-antigen-receptor natural killer (CAR-NK) cell therapies, molecular mechanisms and cellular properties required to achieve clinical benefits in broad cancer spectra remain underexplored. While in vitro and in vivo experiments are required in this endeavor, they are typically expensive, laborious, and limited to targeted investigations.
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333 Agent-based modeling of tumor microenvironment dynamics in adoptive cell therapy

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By Yujia Wang, May Daher, Vakul Mohanty, Stefano Casarin
| The BMJ Verified
http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial.
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