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Stefanos Giannakopoulos

As seen in: Wiley Online Library, PLOS, BioRxiv
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Articles by Stefanos Giannakopoulos

SARS-CoV-2-induced cytokine storm drives prolonged testicular injury and functional impairment in mice that are mitigated by dexamethasone

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By Stefanos Giannakopoulos, Jin Pak, Jackson Bakse, Monika A Ward, PLOS Pathogens
| PLOS
Loading metrics Open Access Peer-reviewed Research Article Citation: Giannakopoulos S, Pak J, Bakse J, Ward MA, Nerurkar VR, Tallquist MD, et al. (2025) SARS-CoV-2-induced cytokine storm drives prolonged testicular injury and functional impairment in mice that are mitigated by dexamethasone. PLoS Pathog 21(1): e1012804.
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Post‐COVID pulmonary injury in K18‐hACE2 mice shows persistent neutrophils and neutrophil extracellular trap formation

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By Stefanos Giannakopoulos, Juwon Park Verified, Jin Pak, Michelle D. Tallquist
| Wiley Online Library Verified
To the Editor, Almost 10%–30% of coronavirus disease 2019 (COVID-19) survivors experience several lingering pulmonary complications, including dyspnea, chronic cough, and pulmonary fibrosis after initial recovery, known as long COVID or postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (PASC).1 The pathogenesis of PASC is complex and multifactorial, and underlying mechanisms, specifically, the characterization of immune dysregulation, and whether the...
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SARS-CoV-2 infection leads to sustained testicular injury and functional impairments in K18 hACE2 mice

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By Stefanos Giannakopoulos, Jin Pak, Monika A Ward, Jackson Bakse
| BioRxiv
Abstract Compromised male reproductive health is one of the symptoms of long COVID with a decrease in male fertility markers including testosterone levels and sperm count for months in recovering patients. However, the long-term impact of SARS-CoV-2 infection on testicular injury and underlying mechanisms remains unknown. We previously demonstrated a disrupted tissue architecture with no evidence of virus replication in the testis during the acute stage of the disease in K18-hACE2 mice.
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In vitro evidence against productive SARS-CoV-2 infection of human testicular cells: Bystander effects of infection mediate testicular injury

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By Daniel Strange, Boonyanudh Jiyarom, Stefanos Giannakopoulos, Omar Abdelaal, PLOS Pathogens
| PLOS
SARS-CoV-2 envelope protein causes severe damage in testicular cells Virus-induced bystander cell death can be due to both inflammatory cytokines and/or viral proteins secreted by infected cells in the bloodstream, as shown in other viruses like Dengue and Ebola [37,38]. As a result, we investigated whether SARS-CoV-2 S1, N, and E proteins can cause cytopathic effects in various testicular cells.
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