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Steffen Uebe

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Articles by Steffen Uebe

Proteasomal activation ameliorates neuronal phenotypes linked to FBXO11-deficiency

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By Anne Gregor, Arif B. Ekici, Philipp Kirchner, Steffen Uebe, Mandy Krumbiegel, Christiane Zweier, Laila Distel, Soeren Turan
| Cell Press Verified
1Department of Human Genetics, Inselspital University Hospital Bern, University of Bern, 3010 Bern, Switzerland 2Department for Biomedical Research (DBMR), University of Bern, 3010 Bern, Switzerland 3Institute of Human Genetics, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen, Germany 4Institute of Tissue Medicine and Pathology, University of Bern, 3010 Bern, Switzerland 5Department of Stem Cell Biology, Friedrich-Alexander-Universität Erlangen-Nürnberg, 91054 Erlangen,...
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PU.1 controls fibroblast polarization and tissue fibrosis

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By Simon Rauber, Thomas Wohlfahrt, Steffen Uebe, Markus Luber
| Nature Verified
Abstract Fibroblasts are polymorphic cells with pleiotropic roles in organ morphogenesis, tissue homeostasis and immune responses. In fibrotic diseases, fibroblasts synthesize abundant amounts of extracellular matrix, which induces scarring and organ failure. By contrast, a hallmark feature of fibroblasts in arthritis is degradation of the extracellular matrix because of the release of metalloproteinases and degrading enzymes, and subsequent tissue destruction.
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