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Articles by Stephan Eckert
Pathogenesis of diffuse large B cell lymphoma proteogenotypes
Keywords lymphoma genomics proteomics tumor microenvironment immune exhaustion multi-omics data integration MYC B cell receptor single cell sequencing protein translation Introduction Diffuse large B cell lymphoma (DLBCL) is a genetically and clinically heterogeneous disease. While about 60–70% of patients with DLCBL can be cured with R-CHOP chemoimmunotherapy, 30–40% relapse or are refractory to treatment.
Towards routine proteome profiling of FFPE tissue: Insights from a 1,200 case pan-cancer study
Abstract Proteome profiling of formalin-fixed paraffin-embedded (FFPE) specimens has gained traction for the analysis of cancer tissue for the discovery of molecular biomarkers. However, reports so far focused on single cancer entities, comprised relatively few cases and did not assess the long-term performance of experimental workflows. Here, we did so by analyzing 1,220 tumors from six cancer entities processed over the course of three years.
Decrypting the molecular basis of cellular drug phenotypes by dose-resolved expression proteomics - Nature Biotechnology
Abstract Proteomics is making important contributions to drug discovery, from target deconvolution to mechanism of action (MoA) elucidation and the identification of biomarkers of drug response. Here we introduce decryptE, a proteome-wide approach that measures the full dose–response characteristics of drug-induced protein expression changes that informs cellular drug MoA.
Die größten Probleme in der OEM-Belieferung
Üblicherweise werden die Abrufe eines OEMs elektronisch in Form von EDI-Nachrichten (Electronic Data Interchange) an den Lieferanten übermittelt. Dieser muss in der Lage sein, die eingehenden Daten zu konvertieren, auszulesen und in sein System zu übernehmen. Bei der Auslieferung müssen diese Daten immer noch korrekt vorliegen und im Lieferavis oder auch in Lieferdokumenten und -etiketten übernommen werden. Was gehört zur OEM-Belieferung?
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