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Stephen Barat

As seen in: American Society for Microbiology (ASM)
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Articles

A Second-Generation Fungerp Analog, SCY-247, Shows Potent In Vitro Activity against Candida auris and Other Clinically Relevant Fungal Isolates

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By Lisa Long, Thomas McCormick, Stephen Barat
| American Society for Microbiology (ASM)
Experimental Therapeutics Sherman Chu, Lisa Long, Rania Sherif, Thomas S. McCormick, Katyna Borroto-Esoda, Stephen Barat, Mahmoud A. Ghannoum DOI: 10.1128/AAC.01988-20 ABSTRACT Due to the increase of antifungal drug resistance and difficulties associated with drug administration, new antifungal agents for invasive fungal infections are needed. SCY-247 is a second-generation fungerp antifungal compound that interferes with the synthesis of the fungal cell wall polymer β-(1,3)-d-glucan.
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A Second-Generation Fungerp Analog, SCY-247, Shows Potent In Vivo Activity in a Murine Model of Hematogenously Disseminated Candida albicans

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By Lisa Long, Thomas McCormick, Stephen Barat
| American Society for Microbiology (ASM)
Experimental Therapeutics Sherman Chu, Lisa Long, Thomas S. McCormick, Katyna Borroto-Esoda, Stephen Barat, Mahmoud A. Ghannoum DOI: 10.1128/AAC.01989-20 ABSTRACT Echinocandins are a first-line therapy for Candida infections through their ability to inhibit the synthesis of polymer β-(1,3)-d-glucan. However, there has been an emergence of multidrug-resistant fungal species necessitating the development of novel antifungal agents to combat invasive fungal infections.
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