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Stephen Bela Kovacs on Muck Rack

Stephen Bela Kovacs

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Articles

Caspase-1 activates gasdermin A in non-mammals

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By Bo Wei, Kidong Kang, Zachary Paul Billman, Stephen Bela Kovacs
| eLife
eLife assessment This study presents valuable insights into the evolution of the gasdermin family, making a strong case that a GSDMA-like gasdermin activated by caspase-1 cleavage was already present in early land vertebrates. Convincing biochemical evidence is provided that extant avian, reptilian, and amphibian GSDMA proteins can still be activated by caspase-1 and upon cleavage induce pyroptosis-like cell death -- at least that they do so in the context of human cell lines.
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