Steven G. Rozen

Abstract Mutational signatures are characteristic patterns of mutations caused by endogenous mutational processes or by exogenous mutational exposures. There has been little benchmarking of approaches for determining which signatures are present in a sample and estimating the number of mutations due to each signature. This problem is referred to as "signature attribution".

Abstract Mutational signatures are characteristic patterns of mutations caused by endogenous mutational processes or by exogenous mutational exposures. There has been little benchmarking of approaches for determining which signatures are present in a sample and estimating the number of mutations due to each signature. This problem is referred to as "signature attribution".

Abstract Mutational signatures are characteristic patterns of mutations caused by endogenous mutational processes or by exogenous mutational exposures. Much research has focused on the problem of inferring mutational signatures as latent variables in somatic mutation data from multiple tumors. However, the problem of determining which signatures are present in a given sample and how many mutations each signature is responsible for has received negligible attention.