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Writer. Host of the Infinite Inning podcast. Author Forging Genius: Casey Stengel, Former E-i-C/current Consulting Editor of Baseball Prospectus.
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Abstract Treatment of neurological diseases that involve oligodendrocytes or astrocytes would benefit from the selective delivery of viral vectors to their common parent, glial progenitor cells (GPCs). Here, we select adeno-associated virus (AAV) capsids with tropism for human GPCs and demonstrate efficient and widespread delivery of the resultant AAVs throughout the mouse brain through the glymphatic system.