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Steven W. Barger on Muck Rack

Steven W. Barger

As seen in: Color Research & Application, Nature, Frontiers, MDPI, Taylor & Francis Online
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Articles

Microglial serine racemase knockout alleviates Alzheimer-like neuropathology and behavioral deficit via lactylation-mediated anti-inflammation - Communications Biology

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By Jing Zhou, Yuanhong Yang, Shuyi Liu, Juan Chen, Wenjing Liang, Zhiwen Zhang, Yan Wang, Yimei Liu, He Zhang, HaiYan Jiang, Jia Qu, Steven W. Barger, Shengzhou Wu, Hongji Liao, Wenchu Lin
| Nature Verified
Abstract Serine racemase (SR) dysregulation associates with brain aging and Alzheimer’s disease (AD), as both a deficiency and an excess of D-serine can impact synaptic neurotransmission and the integrity of synapses. Neuronal SR decreases with aging, while glial SR is upregulated in AD. However, the role of SR in microglia involved in AD remains elusive. Here, Srr knockdown/knockout in microglia enhanced whereas overexpression of SR inhibited phagocytosis.
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Frontiers | Modulation of apolipoprotein E receptor-2 by ApoE4, amyloid β-peptide, reelin, and secreted amyloid precursor protein: a common point of impact in Alzheimer’s disease pathogenesis

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By Steven W. Barger
| Frontiers
Abstract Introduction: Apolipoprotein E (ApoE), reelin, and several other proteins bind ApoE-receptor 2 (apoER2), distinguished from other members of its receptor family by signal transduction which enhances the activity of N-methyl D-aspartate (NMDA) receptors. Evidence indicates that this signal transduction depends upon apoER2 forming dimers or other high-order clusters.
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P-glycoprotein and Alzheimer’s Disease: Threats and Opportunities

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By Steven W. Barger
| Taylor & Francis Online
Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that affects more than 50 million people worldwide. One of the hallmark features of AD is the accumulation of amyloid β-peptide (Aβ) protein in the brain. P-glycoprotein (P-gp) is a membrane-bound protein expressed in various tissues, including the cerebrovascular endothelium. It plays a crucial role in the efflux of toxic substances, including Aβ, from the brain.
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