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Stine Asmussen

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Articles

The role of aging and brain‐derived neurotrophic factor signaling in expression of base excision repair genes in the human brain

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By Sofie Lautrup, Camilla Myrup Holst, Anne Yde, Stine Asmussen
| Wiley Online Library Verified
BDNF treatment stimulates BER in primary hippocampal neurons Besides the extend of CREB binding to CRE sites, induction of gene expression by CREB depends on its activation as occurs via, for example, BDNF signaling. Our correlative BDNF findings in the human brain (Figure 1) and our CREB-binding studies (Figure 2) suggest that BDNF possibly via CREB could be a major regulator of BER gene transcription. Therefore, we wanted to explore whether there is a causative connection between BDNF and BER.
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