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To investigate relationships between glycated haemoglobin (HbA1c) and reported hypoglycaemia and risk of major adverse cardiovascular (CV) events (MACE). The EXAMINE trial randomized 5380 patients in 49 countries with type 2 diabetes (T2DM) and a recent acute coronary syndrome (ACS) to double-blind treatment with alogliptin or placebo in addition to standard of care. We used Cox proportional hazards models to analyze relationships among MACE, HbA1c levels and hypoglycaemia events.
Cardiovascular Mortality in Patients With Type 2 Diabetes and Recent Acute Coronary Syndromes From the EXAMINE Trial William B. White, Stuart Kupfer, Faiez Zannad, Cyrus R. Mehta, Craig A. Wilson, Lanyu Lei, George L. Bakris, Steven E. Nissen, William C. Cushman, Simon R. Heller, Richard M. Bergenstal, Penny R. Fleck, Christopher P. Cannon Diabetes Care Jul 2016, 39 (7) 1267-1273; DOI: 10.2337/dc16-0303
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