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Stuelten CH

As seen in: AHA/ASA Journals
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Articles

Role of PAR1-Egr1 in the Initiation of Thoracic Aortic Aneurysm in Fbln4-Deficient Mice

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By DaCosta Byfield S, Arany PR, Stuelten CH, Karpova TS
| AHA/ASA Journals
Highlights Mechanical stress responsive transcription factor Egr1 (early growth response 1) is involved in the pathogenesis of aortic aneurysm in smooth muscle cell-specific fibulin-4 knockout (SMKO) mice. Egr1, PAR1 (protease activated receptor 1), and active thrombin are abundant in the aneurysm lesions in SMKO mice and human patients with thoracic aortic aneurysms. Activation of PAR1 by thrombin, MMP (matrix metalloproteinase)-9, and mechanical stimuli initiates ascending aortic aneurysms.
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