SuFey Ong on Muck Rack

SuFey Ong

As seen in: The Journal of Immunology
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Articles

The role of c-Ski and TGFβ signaling in autoimmunity

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By Steven F Ziegler, SuFey Ong, Mathias Hauri-Hohl
| The Journal of Immunology Verified
TGFβ is involved in both T and Th differentiation via its induction of Foxp3 and RORγt. The oncogene c-ski regulates TGFβ function by inhibiting SMAD2/3 from both binding to SMAD4 and to DNA, repressing the transcription of TGFβ-inducible genes. Previously, we have shown that the absence of ski in medullary thymic epithelial cells (mTECs) limits cellular growth due to unchecked TGFβ signaling.
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