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Sug Hyung Lee on Muck Rack

Sug Hyung Lee

As seen in: Color Research & Application, Nature
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Articles

NF-κB-active tumors with matrix CAFs and suppressive immunity as key resistance mechanisms to chemoradiation in rectal cancer

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By Junseong Park, Sun Hye Shin, Dokyeong Kim, Sumin Cho, Hyun Kim, Sug Hyung Lee, Jae Woong Kim, Changhyeok An
| Nature Verified
Abstract Most patients with intermediate-to-high-risk locally advanced rectal cancer (LARC) undergo neoadjuvant chemoradiotherapy (NCRT), but reliable predictive biomarkers and well-defined resistance mechanisms remain lacking. We sought biomarkers and molecular mechanisms of NCRT resistance in LARC. We analyzed paired pre-NCRT and post-NCRT biopsies from 26 patients with intermediate-to-high-risk LARC using single-cell RNA sequencing and spatial transcriptomics.
Open in Who Shared Issue with article?

Intraindividual genomic heterogeneity of high-grade serous carcinoma of the ovary and clinical utility of ascitic cancer cells for mutation profiling

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By Min Kim, Sung Lee, Youn Jin Choi, Je-Keun Rhee, Soo Young Hur, Yeun-Jun Chung, Tae-Min Kim, Sug Hyung Lee
| Color Research & Application Verified
Intraindividual tumoural heterogeneity (ITH) is a hallmark of solid tumours and impedes accurate genomic diagnosis and selection of proper therapy. The aim of this study was to identify ITH of ovarian high-grade serous carcinomas (OSCs) and to determine the utility of ascitic cancer cells as a resource for mutation profiling in spite of ITH.
Open in Who Shared Issue with article?
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