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Suhkneung Pyo

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Articles

Inhibition of LPS-induced inflammatory mediators by 3-hydroxyanthranilic acid in macrophages through suppression of PI3K/NF-κB signaling pathways

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By Kyoungran Lee, Jong Hwan Kwak, Suhkneung Pyo
| Chemistry World Verified
Many tryptophan metabolites have immunomodulatory effects on various immune cells. 3-Hydroxyanthranilic Acid (3-HAA) is a tryptophan metabolite reported to have anti-inflammatory activity. The mechanism of this activity is unclear. The present study examined the immumodulatory effects and molecular mechanisms of 3-HAA on macrophages. Pretreatment of 3-HAA (0.1 - 10 μg/mL) for 2 h markedly inhibited NO and cytokine production in LPS-stimulated Raw 264.7 macrophages.
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