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Suizhen Lin on Muck Rack

Suizhen Lin

As seen in: Color Research & Application
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Hexokinase 2-dependent Hyperglycolysis Driving Microglial Activation Contributes to Ischemic Brain Injury

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By Yuan Li, Bingzheng Lu, Longxiang Sheng, Zhu Zhu, Wenli Chen, Yun Du, Pengxin Qiu, Xingwen Su, Yijun Huang, Wei YIN, Hongjiaqi Sun, Yuwei Zhou, Dongdong Xue, Xuyan Tian, Wenbo Zhu, Suizhen Lin, Guangmei Yan
| Color Research & Application Verified
Hyperglycolysis, observed within the penumbra zone during brain ischemia, was shown to be detrimental for tissue survival due to lactate accumulation and reactive oxygen species (ROS) overproduction in clinical and experimental settings. Recently, mounting evidence suggests that glycolytic reprogramming and induced metabolic enzymes can fuel the activation of peripheral immune cells.
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