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Articles by Sujata Kumari
p66Shc mediates SUMO2-induced endothelial dysfunction
eLife Assessment This study offers valuable insights into the role of post-translational modifiers, specifically SUMO2ylation at K81 in p66Shc, and its impact on endothelial function through reactive oxygen species. A series of compelling experiments demonstrated that lysine 81 of p66Shc is the site of SUMO2 conjugation, which is crucial for mitochondrial localization and essential for S36 phosphorylation, leading to specific pathological effects.
P66Shc Mediates SUMO2-induced Endothelial Dysfunction
Abstract Background: Sumoylation is a post-translational modification that can regulate different physiological functions. Increased sumoylation, specifically conjugation of SUMO2/3 (small ubiquitin-like modifier 2/3), is detrimental to vascular health. However, the molecular mechanism mediating this effect is poorly understood. Methods: We used cell-based assays and mass spectrometry to show that p66Shc is a direct target of SUMO2 and SUMO2 regulates p66Shc function via lysine-81 modification.
P66Shc Mediates SUMO2-induced Endothelial Dysfunction
Abstract Sumoylation is a post-translational modification that can regulate different physiological functions. Increased sumoylation, specifically conjugation of SUMO2/3 (small ubiquitin like modifier 2/3), is detrimental to vascular health. However, the molecular mechanism mediating this effect is poorly understood. Here, we demonstrate that SUMO2 modifies p66Shc, which impairs endothelial function.
Morpho-Biochemical Responses of Brassica Coenospecies to Glyphosate Exposure at Pre- and Post-Emergence Stages
Abstract : Crop wild relatives (CWRs) belonging to the Brassicaceae family possess extensive genetic diversity and have frequently been utilized in the enhancement of cultivated Brassica species. However, their tolerance to glyphosate, a widely used herbicide, has remained unknown. Our study examined the glyphosate response of 20 genotypes from the Brassicaceae family, which included genotypes within the U triangle and their wild relatives.
Indexing Resilience to Heat and Drought Stress in the Wild Relatives of Rapeseed-Mustard
3.4. Identification of Tolerant Genotypes Based on Correlation, PCA, Tolerance Index (TI) and Membership Function Value (MFV) The Pearson correlation coefficient ® was calculated to demonstrate the association among various observed traits in the individual experiments. In heat stress, no strong correlation between the morphological traits studied and between the survival percentage and MDA content was observed (Table 3 and Table 4).
Age Estimation by Dental Calcification Stages and Hand-Wrist Radiograph
The notion of physiological age was developed as a way to measure the progress of a child's growth or maturity because of the disparities in the developmental stages of distinct biological systems. Child dentition may be utilized as one of the skeletal approaches for physiological age assessment since children of the same chronological age have a wide range of development [11]. The Demirjian technique is extremely accurate and has a strong correlation with chronological age [12].
Loss of Hepatic Oscillatory Fed microRNAs Abrogates Refed Transition and Causes Liver Dysfunctions
Highlights • Anticipatory hepatic fed miRNAs are essential to attenuating fasting response • RISC association of miRNA-mRNA pairs oscillates during fed-fast cycles in the liver • Convergent additive action of miRNAs governs metabolic and mitochondrial homeostasis • Scavenging fed miRNAs impairs refed transition and affects whole-body energetics Summary Inability to mediate fed-fast transitions in the liver is known to cause metabolic dysfunctions and diseases.
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