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Sukhvinder S. Sidhu on Muck Rack

Sukhvinder S. Sidhu

As seen in: Frontiers in Immunology
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Articles

Development of humanized mouse models for the preclinical evaluation of NK cell-based therapies

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By Pauline Rettman, Georges Azar, Valeria Fantin, Samira Benhamouche-Trouillet, Sukhvinder S. Sidhu
| Frontiers in Immunology
Abstract Introduction: Novel immunotherapeutic strategies engaging human Natural Killer (huNK) cells have emerged as a promising treatment paradigm; however, their accurate preclinical evaluation requires reliable mouse models capable of supporting functional huNK cell engraftment. Methods: We developed and characterized robust in vivo NK-humanized mouse models using immunodeficient human Interleukin-15 (huIL-15) transgenic (Tg) mice.
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