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Suleima Jacob-Tomas on Muck Rack

Suleima Jacob-Tomas

As seen in: MDPI, BioRxiv
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Articles

Impact of histone deacetylase inhibition and arimoclomol on heat shock protein expression and disease biomarkers in primary culture models of familial ALS

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By Suleima Jacob-Tomas, Javeria Rizwan, Mario Fernandez Comaduran, Sandra Minotti
| BioRxiv
Abstract Protein misfolding and mislocalization are common themes in neurodegenerative disorders, including the motor neuron disease, amyotrophic lateral sclerosis (ALS). Maintaining proteostasis is a crosscutting therapeutic target, including upregulation of heat shock proteins (HSP) to increase chaperoning capacity. Motor neurons have a high threshold for upregulating stress inducible HSPA1A, but constitutively express high levels of HSPA8.
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Localized synthesis of molecular chaperones sustains neuronal proteostasis

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By Celia Alecki, Phuong Le, Suleima Jacob-Tomas, Javeria Rizwan
| BioRxiv
Abstract Neurons are challenged to maintain proteostasis in neuronal projections, particularly with the physiological stress at synapses to support intercellular communication underlying important functions such as memory and movement control. Proteostasis is maintained through regulated protein synthesis and degradation and chaperone-assisted protein folding.
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Analysis of the Expression and Subcellular Distribution of eEF1A1 and eEF1A2 mRNAs during Neurodevelopment

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By Ryan Huang, Suleima Jacob-Tomas, Zoe Wefers, Celia Alecki
| MDPI
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