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Sumaiya Nazeen on Muck Rack

Sumaiya Nazeen

As seen in: Genome Biology, BioRxiv, eLife
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Articles

NERINE reveals rare variant associations in gene networks across multiple phenotypes and implicates an SNCA-PRL-LRRK2 subnetwork in Parkinson's disease

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By Sumaiya Nazeen, Xinyuan Wang, Autumn Morrow, Ronya Strom
| BioRxiv
Abstract Gene networks encapsulate biological knowledge, often linked to polygenic diseases. While model system experiments generate many plausible gene networks, validating their role in human phenotypes requires evidence from human genetics. Rare variants provide the most straightforward path for such validation.
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Deep sequencing of proteotoxicity modifier genes uncovers a Presenilin-2/beta-amyloid-actin genetic risk module shared among alpha-synucleinopathies

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By Sumaiya Nazeen, Xinyuan Wang, Dina Zielinski, Isabel Lam
| BioRxiv
Abstract Whether neurodegenerative diseases linked to misfolding of the same protein share genetic risk drivers or whether different protein-aggregation pathologies in neurodegeneration are mechanistically related remains uncertain. Conventional genetic analyses are underpowered to address these questions.
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The missing link between genetic association and regulatory function

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By Byers PH, Noah Connally, Sumaiya Nazeen, Daniel Lee
| eLife
We believe that the genes we have selected have a high probability of mediating GWAS associations, given both their relevance to cognate traits and their enriched proximity to GWAS peaks. But the reviewer suggestion to incorporate genes from Backman et al. is a good one. In addition to providing additional genes to test, the genes from Backman et al. are identified based on analysis of the same complex traits—not their Mendelian cognates.
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