Sumati Rajagopalan on Muck Rack

Sumati Rajagopalan

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Articles

The fetal trophoblast cell marker HLA-G activates a type I interferon response in primary NK cells through the receptor KIR2DL4

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By Sumati Rajagopalan, Saurav Majumder, Christiana Wang, Winston Hibler, Amirhossein Shamsaddini, Paul J. Gardina, Eric Long
| Science Magazine Verified
Editor’s summary The fetus is protected from pathogens by maternal natural killer (NK) cells in the decidua, the lining of the uterus that develops during pregnancy. Rajagopalan et al. characterized the response of the NK cell receptor KIR2DL4 to activation by HLA-G, which is expressed by fetal cells that invade the decidua.
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NK cell-induced damage to P.falciparum-infected erythrocytes requires ligand-specific recognition and releases parasitophorous vacuoles that are phagocytosed by monocytes in the presence of immune IgG

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By Padmapriya Sekar, Sumati Rajagopalan, Estela Shabani, PLOS Pathogens
| PLOS
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Sekar P, Rajagopalan S, Shabani E, Kanjee U, Schureck MA, Arora G, et al. (2023) NK cell-induced damage to P.falciparum-infected erythrocytes requires ligand-specific recognition and releases parasitophorous vacuoles that are phagocytosed by monocytes in the presence of immune IgG. PLoS Pathog 19(11): e1011585. https://doi.org/10.1371/journal.ppat.1011585 Editor: James G.
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NK cell-induced damage to P. falciparum-infected erythrocytes requires ligand-specific recognition and releases parasitophorous vacuoles that are phagocytosed by monocytes in the presence of immune IgG

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By Sumati Rajagopalan, Usheer Kanjee, Padmapriya Sekar, Estela Shabani
| biorxiv.org
New Results doi: https://doi.org/10.1101/2023.07.31.551226 Abstract Natural killer (NK) cells lyse virus-infected cells and transformed cells through polarized delivery of lytic effector molecules into target cells. We have shown that NK cells lyse Plasmodium falciparum-infected red blood cells (iRBC) via antibody-dependent cellular cytotoxicity (ADCC).
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