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Sumeru Panta

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Articles

Structural basis of the regulation by CDK11 kinase of early spliceosome activation and evidence for its proofreading by DHX15 helicase

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By Zhenwei Zhang, VINAY KUMAR Verified, Jiayun Zhong, Olexandr Dybkov, Haohao Dong, Berthold Kastner, Henning Urlaub, Holger Stark, Reinhard Lührmann, Sumeru Panta
| Nature Verified
Abstract Formation of the activated human spliceosome (Bact) involves major structural rearrangements, leading to the catalytically active U2/U6 RNA core. This process involves at least two intermediates, pre-Bact-1 and pre-Bact-2, and is regulated by CDK11-mediated phosphorylation of the U2 snRNP protein SF3B1. However, the mechanisms of this essential step are poorly understood.
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