Sumire Kurosawa

1 Introduction Biotin (vitamin B7) is an essential cofactor for carboxylation, decarboxylation, and transcarboxylation reactions that underpin central metabolism, including fatty acid biosynthesis and gluconeogenesis [1, 2]. In bacteria, biotin-dependent enzymes are critical for maintaining metabolic homeostasis and membrane lipid biosynthesis, processes that are closely linked to pathogenicity and antibiotic resistance.

Introduction Click to copy section linkSection link copied! Pyrrolamides constitute a family of natural products featuring a pyrrole-2-carboxamide core in their structures. These linear peptidic compounds are produced by Streptomyces species, first represented by congocidine (also known as netropsin), isolated from Streptomyces ambofaciens in the 1950s (Figure 1a).