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In Situ Single-Cell Spatial Profiling of Matrisome Gene Expression in Glioblastoma

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By Arpan De, Santiago A. Forero, John Morales, Sumod Sebastian
| biorxiv.org
Abstract Glioblastoma (GBM) is the most common and aggressive primary brain cancer in adults, characterized by robust infiltrative growth and invasion in the neural microenvironment. While various stromal cells including astrocytes, microglia, and vascular cells in the microenvironment communicate with GBM cells to promote growth and invasion, relatively less is known about the other critical component of the tumor stroma: the extracellular matrix (ECM).
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