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IGHG1 对急性髓系白血病THP-1 细胞增殖、凋亡和侵袭的机制研究
Abstract: Objective To investigate the expression of immunoglobulin γ-1 heavy chain constant region (IGHG1) in acute myeloid leukemia (AML) THP-1 cells and its influence on cell proliferation, apoptosis, and invasion via its regulation of the transforming growth factor β (TGF-β) / Smad pathway. Methods Bone marrow specimens from nine children with AML and eight children with fractures, human bone marrow stromal HS-5 cells, and human AML THP-1 and HL60 cells were used in the research.
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